Medical diagnostics and therapeutics

Our research on biosensing and therapeutics spans a large range of topics. We explore the broad range of applications of electrical and electronic systems in medical diagnostics, therapeutics, and imaging. We have developed low-cost handheld magnetic spectroscopic platforms for highly multiplexed medical diagnostics and demonstrated magnetics bioassays for both proteomics and nucleic acid detection. We have also demonstrated the usage of the magnetic detection platforms in a cell-based rapid highly parallel drug-screening platform. This has led to a magnetic spectroscopic handheld system capable of doing magnetic multiplexing akin to the optical fluorescent tagging with multiple colors. Additionally, we are actively involved in a dynamic magnetic manipulation platform that generates a dynamically programmable magnetic field using a sophisticated magnetic field generation system we have developed to route and direct microglia (MG) and macrophages (MP), carrying magnetic nano-particles to the tumor site. We have extensive experience with electronic instrumentation and sensing system and have several project based on various magnetic sensing and actuation modalities for various biological applications. We have also used silicon integrated circuit technology to develop a low-cost handheld terahertz imager system to investigate the response of various kinds of normal and abnormal epithelial cells with a long-term target of applying this as an early detection and screening device. The non-ionizing nature of the terahertz radiations is an additional attraction to this imaging modality.

Silicon Integrated 280 GHz Imaging Chipset With 4×4 SiGe Receiver Array and CMOS Source

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Functionalized iron oxide nanoparticles for controlling the movement of immune cells

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Design and Implementation of an Integrated Magnetic Spectrometer for Multiplexed Biosensing

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A handheld magnetic sensing platform for antigen and nucleic acid detection

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A Handheld Magnetic Sensing Platform for Antigen and Nucleic Acid Detection

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An Integrated Magnetic Spectrometer for Multiplexed Biosensing

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A magnetic cell-based sensor

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A Frequency-Shift based CMOS Magnetic Biosensor with Spatially Uniform Sensor Transducer Gain

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An Ultrasensitive CMOS Magnetic Biosensor Array with Correlated Double Counting Noise Suppression

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A Spectral-Scanning Nuclear Magnetic Resonance Imaging (MRI) Transceiver

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A Frequency-Shift CMOS Magnetic Biosensor Array with Single-Bead Sensitivity and No External Magnet

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A Spectral-Scanning Magnetic Resonance Imaging (MRI) Integrated System

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On Noise Processes and Limits of Performance in Biosensors

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