Cell Culture and Cell Based Sensor on CMOS

H. Wang, A. Mahdavi, J. Park, T. Chi, J. Butts, T. Hookway, T. McDevitt, D. Tirrell, and A. Hajimiri

This paper focuses on CMOS biosensor technologies for cellular biosensing applications. We first present our technologies to achieve on-CMOS cell culture, maintenance, and differentiation, as the basis for CMOS cellular biosensors. Next, we introduce a CMOS frequency- shift magnetic sensor scheme which performs detections without post-processing or external biasing magnetic field. Finally, we will demonstrate a CMOS magnetic cell based sensor which achieves real-time chemical detections; such a sensor scheme can be utilized for massively paralleled high- throughput chemical screening in drug development.